Nociceptive threshold evaluated using the electronic mechanical threshold test after CFA-induced experimental pain model. (A) Effect of capsaicin on TRPV1 at 0.03, 0.3, and 3.0 µg/ 20 µL concentrations. (B) Effect of menthol on TRPM8 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. (C) Effect of methyl salicylate on TRPA1 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. Statistical analysis was performed using one-way ANOVA, followed by Bonferroni post hoc test. *p < 0.05 compared to saline; # represents p < 0.05 compared to the other treatments (#).|@|~(^,^)~|@|Withdrawal latency using the tail-flick test (TF). (A) Effect of capsaicin on TRPV1 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. (B) Effect of menthol on TRPM8 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. (C) Effect of methyl salicylate on TRPA1 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. Statistical analysis was performed using one-way ANOVA, followed by Bonferroni post hoc test. *p < 0.05 compared to saline; # represents p < 0.05 compared to the other treatments (#).|@|~(^,^)~|@|Nociceptive threshold evaluated using the electronic mechanical threshold test following CCI experimental model. (A) Effect of capsaicin on TRPV1 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. (B) Effect of menthol on TRPM8 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. (C) Effect of methyl salicylate on TRPA1 at 0.03, 0.3, and 3.0 µg/20 µL concentrations. Statistical analysis was performed using one-way ANOVA, followed by Bonferroni post hoc test. *p < 0.05 compared to saline; # represents p < 0.05 compared to the other treatments (#).

J Acupunct Meridian Stud 2022;15:105~113 https://doi.org/10.51507/j.jams.2022.15.2.105