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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

2020; 13(2): 77-77

Published online April 1, 2020 https://doi.org/10.1016/j.jams.2020.03.036

Copyright © Medical Association of Pharmacopuncture Institute.

Cannabinoid synthesis and accumulation in glandular trichomes of Cannabis sativa

Eun Soo Kim

Korea Hemp Institute, Konkuk University, South Korea

http://creativecommons.org/licenses/by-nc-nd/4.0/

Abstract

Glandular trichomes are known to be the sites of cannabinoid accumulation in Cannabis sativa. They cover the surface of the aboveground plant parts but are most abundant on the floral bracts of pistillate plants. This study conducted to determine where the cannabinoids are synthesized and localized at the whole-plant level and at the cellular level using micromanipulation and transmission electron microscopy. According to their external features, three types of glandular trichomes are recognized: bulbous, capitate-sessile, and capitate-stalked trichomes. The gland head consist of disc cells containing cytoplasm and a non-cellular intrawall secretory cavity. The lipoplasts in the disc cells of globose heads synthesize lipophilic terpenes that migrate through the plasma membrane and into the cell wall adjacent to the secretory cavity. They subsequently pass through the cell wall and accumulate in the secretory cavity in the form of secretory vesicles. Numerous vesicles of different sizes and densities are localized in the secretory cavity. In conclusion, lipophilic terpenes and phenols, when released from their respective lipoplasts and vacuole compartments, accumulate in the plasma membrane/cell wall interface, where enzymes combine these precursors into cannabinoids. Mature glands possess the highest concentration of major cannabinoids, such as CBD in the fiber strains and THC in the drug strains of Cannabis sativa.

Keywords: Cannabis, cannabinoid, glandular trichome, lipoplast, secretory cavity, terpene

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