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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

2020; 13(2): 72-73

Published online April 1, 2020 https://doi.org/10.1016/j.jams.2020.03.018

Copyright © Medical Association of Pharmacopuncture Institute.

Electroacupuncture in Essential Hypertension: Over-Excitation of Sympathetic Tone

Stephanie C. Tjen-A-Looi

Susan Samueli Integrative Health Institute, College of Health Sciences, University of California, Irvine, United States

http://creativecommons.org/licenses/by-nc-nd/4.0/

Abstract

Essential hypertension a multifactorial pathophysiological condition involves many systems including the sympathetic nervous system. Increased sympathetic activity contributes to the elevation of blood pressure during sympathoexcitatory cardiovascular reflex responses as well as in hypertension. We have shown that electroacupuncture (EA) reduces sympathoexcitation and both reflex elevations of blood pressure and hypertension in animals and humans. In addition, EA reduces sympathoexcitatory blood pressure responses in hypertensive subjects. Elevated blood pressure also is reduced with manual acupuncture and moxibustion. Hypothalamic to medullary cardiovascular regions in the brain process the actions of EA, manual acupuncture and moxibustion involving specific mechanisms during sympathoexcitation. Recent investigations focused on the peripheral mechanisms at the acupoint site during EA, manual acupuncture and moxibustion. We hypothesized that the transient receptor potential vanilloid (TRPV1) peripheral local mechanism at the acupoint site is involved in the blood pressure lowering effect. In anesthetized rats using neurophysiology, siRNA, pharmacology, immunohistochemistry and hemodynamic responses, our data show that peripheral local TRPV1 participates during the blood pressure lowering effect with manual acupuncture and heat sensitive moxibustion but not EA. Mechano sensitive TRPV1 contributes to manual acupuncture activating peripheral somatosensory nerves. In contrast, EA-induced increase of somatosensory activity is not affected by blockade of TRPV1 at the site of acupoint. Similarly, TRPV1 knockdown in dorsal root ganglia (DRG) reduced activation of the peripheral DRG neurons during manual acupuncture but not EA. Sympathoexcitatory increase in blood pressure is reduced by acupoint specific moxibustion through local heat sensitive TRPV1 but not EA. In aggregate, EA, manual acupuncture and moxibustion applied at specific acupoints employ different peripheral local mechanisms to reduce elevated blood pressure and over-excitation of sympathetic activity.

Keywords: manual acupuncture, moxibustion, peripheral and central actions

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