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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

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International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts

2020; 13(2): 72-72

Published online April 1, 2020 https://doi.org/10.1016/j.jams.2020.03.017

Copyright © Medical Association of Pharmacopuncture Institute.

Acupuncture point: One form of neurogenic inflammation in skin

Hee Young Kim

Physiology, Daegu Haany University, South Korea

http://creativecommons.org/licenses/by-nc-nd/4.0/

Abstract

Visceral pain produces hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervation; the spots can be visualized experimentally on the skin by extravasation of Evans blue dye. Here, we show that an acupoint is one form of neurogenic inflammation on the skin. Various studies have demonstrated that acupoints show mechanical hypersensitivity and have high electrical conductance. Stimulation of acupoints produces needling sensations caused by activation of small afferent fibers and therapeutic effects on the associated visceral organs, likely due to the release of endogenous opioids. The present study provides experimental evidence that neurogenic spots exhibit all the characteristics of the acupoints listed above. In addition, the stimulation of neurogenic spots by electrical, mechanical, or chemical means alleviated pathological conditions in rat colitis and hypertension models via endogenous opioid systems. Blocking NK1R in neurogenic spots prevented the acupuncture effects. Elevated substance P and CGRP caused low electrical resistance in neurogenic spots as well as acupoints. Our results demonstrate that an acupoint is identical to a neurogenic inflammatory spot on the skin, which is produced by activation of somatic C-fiber terminals in abnormal conditions of visceral organs. This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)(No.2018R1A5A2025272 and 2018R1D1A1B07046196), KBRI basic research program through Korea Brain Research Institute funded by Ministry of Science and ICT (18-BR-03) and Korea Institute of Oriental Medicine (KIOM) K18181.

Keywords: acupuncture point, neurogenic, visceral pain

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