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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Background and Aim Cordycepin, the major active component from Cordyceps militaris, has been reported to significantly inhibit some types of cancer; however, its effects on ovarian cancer are still not well understood. In this study, we treated human ovarian cancer cells with different doses of cordycepin and found that it dose-dependently reduced ovarian cancer cell viability, based on Cell counting kit-8 reagent. Method and Result Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited β-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas β-catenin overexpression abolished the effects of cordycepin on cell death and proliferation. Furthermore, we found that Dkk1 overexpression by transfection downregulated the expression of c-Myc and cyclin D1. siRNA-mediated Dkk1 silencing downregulated the expression of Atg8, beclin, and LC3 and promoted β-catenin translocation from the cytoplasm into the nucleus. Conclusion These results suggest that cordycepin inhibits ovarian cancer cell growth, possibly through coordinated autophagy and Dkk1/β-catenin signaling. Taken together, our findings provide new insights into the treatment of ovarian cancer using cordycepin.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objective To confirm the exact clinical efficacy of comprehensive treatment of advanced Non-Small Cell Lung Cancer (NSCLC) with Traditional Chinese Medicine (TCM), and to explore the clinical research methods of TCM oncology. Method In this study, 542 patients with advanced non-small cell lung cancer (III A-IV) were enrolled in a large sample, multi-center and prospective cohort study, including 260 patients in the Western Medicine cohort, 114 patients in the Chinese Medicine cohort and 168 patients in the Integrated Chinese and Western Medicine cohort. With PFS, OS and quality of life as the main indicators, the efficacy of comprehensive treatment of traditional Chinese medicine and its predominant population were observed. Result The median survival time was 280 days in the TCM cohort, 381 days in the western medicine cohort, and 465 days in the integrated traditional Chinese and Western medicine cohort. The difference between any two cohort groups was statistically significant (p < 0.0167). It indicated that the median survival time of the Chinese and Western combined cohort was the longest, followed by the western medicine cohort, and the Chinese medicine cohort was the shortest. The median progression-free survival time was 170 days in the TCM cohort, 180 days in the western medicine cohort, and 217 days in the integrated Chinese and Western medicine cohort. There was no statistically significant difference between Chinese medicine cohort and Western medicine cohort. There was statistically significant (p < 0.0167) difference between the TCM cohort and the integrated Chinese and Western medicine cohort. Although the difference between the western medicine cohort and the integrated Chinese and Western medicine cohort was not statistically significant, the results showed that the integrated Chinese and Western medicine cohort had a trend of improving the progression-free survival time compared with the western medicine cohort. The 1-year survival rate was 41% in the TCM cohort, 53% in the western medicine cohort, and 61% in the integrated Chinese and western medicine cohort. The 2-year survival rate was 26% in the western medicine cohort and 35% in the integrative medicine cohort. Conclusion According to the different stages of treatment, choosing the appropriate Chinese herbal medicine treatment can improve the physical condition, clinical symptoms, quality of life, reduce the adverse reactions of digestive tract caused by radiotherapy and chemotherapy for patients with advanced non-surgical lung cancer. It has the effect trend of enhancing the curative effect of radiotherapy and chemotherapy, and can prolong the survival time. Traditional Chinese medicine alone is not inferior to western medicine in disease progression and overall survival, and there are no obvious adverse reactions. Patients with advanced non-small cell lung cancer should be treated with integrated traditional Chinese and Western medicine when conditions permit. Patients with older age and poor physical condition can choose traditional Chinese medicine alone as appropriate.

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Pancreatic cancer is often accompanied by severe abdominal or back pain. It’s the first study to evaluate the analgesic effect of electroacupuncture on pancreatic cancer pain. A randomized controlled trial compared electroacupuncture with control acupuncture using the placebo needle. Methods: Sixty patients with pancreatic cancer pain were randomly assigned to the electroacupuncture group (n ¼ 30) and the placebo control group (n ¼ 30). Patients were treated on Jiaji (Ex-B2) points T8eT12 bilaterally for 30 min once a day for 3 days. Pain intensity was assessed with numerical rated scales (NRS) before the treatment (Baseline), after 3 treatments, and 2 days follow-up. Results: Baseline characteristics were similar in the two groups. After 3 treatment, pain intensity on NRS decreased compared with Baseline (1.67, 95% confidence interval [CI] 1.46 to 1.87) in the electroacupuncture group; there was little change (0.13, 95% CI 0.08 to 0.35) in control group; the difference between two groups was statistically significant (P < 0.001). Follow-up also found a significant reduction in pain intensity in the electroacupuncture group compared with the control group (P < 0.001). Conclusions: Electroacupuncture was an effective treatment for relieving pancreatic cancer pain

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Taegeuk acupuncture treatment which was suggested by Dr. Lee Byung-haeng for the first time in 1974, is based on Korean original Constitutional theory, Sasang Constitutional Medicine. In Dongeui-Susebowon, written by Dr. Lee Jema in 1894, he emphasized the function of heart by saying that heart is Taegeuk at the center among the five viscera organs and rules the other four organs. The name Taegeuk acupuncture was originated from the importance of heart as Taegeuk in Dr. Lee Jema's theory. Sasang Constitution means four types of constitution comprised of Tae-Yang, So-Yang, So-Eum and Tae-Eum. Tae-Yang has a characteristic of metal, So-Yang is fire, So-Eum is water, and Tae-Eum is wood. There are three main acupuncture points related to different charicteristics and dominant organ functions of each constitution. One is among Heart meridian five shu points, and it is used for reinforcing method to restrain the dominant characteristic of each constitution. Another point is yuan-source (primary) point on the weak organ's meridian for reinforcement. The other is yuan-source (primary) point on the strong organ's meridian for reduction. For instance, in case of Tae-Yang, by reinforcing HT8 which has a characteristic of fire among heart meridian five shu points, we can reduce excessive metal-dominant characteristic of Tae-Yang. Since Tae-Yang has a decreased function of liver system, we choose LR3 for reinforcement, and LU9 for reduction of an excessive function of lung system. Therefore, the three main acupuncture points for Tae-Yang consist of HT8(+), LR3(+), and LU9(-). In a clinical practice, LI4, LI11 and ST36 are additionally chosen as representatives of acupoints on the upper and lower extremity. However, the treatment effects seem similar whether or not you choose the three additional points. Therefore, when you treat pediatric patients or patients who are afraid of needles, you can use only the three main points for the treatment. Its clinical applications are psychogenic diseases (e.g. anxiety, depressive mood disorder, Hwa-byung, sleep disorder, etc.), autonomic nerve system disorders, poor blood circulation, chronic pain syndrome (e.g. fibromyalgia), chronic fatigue syndrome, and so on. It can be an effective treatment measure for refractory conditions which show poor response to conventional treatments and other acupuncture techniques. This is because, Taegeuk acupuncture helps patients' own natural healing process by restoring the balance of the human body, regardless of the locations or etiology of the illness. When you have the patient who has one of those conditions listed above, the first thing you have to do is examining epigastric tenderness and hepatic dullness, to identify the patient's constitution before the practice of acupuncture. Correct classification of the constitution is the most important part of the treatment process. Dr. Lee Jema suggested the classification of the four constitutions based on the personality and external appearance. In addition to Dr. Lee Jema's theory, Dr. Lee Byung-haeng checked the response of the patient after treating one point among Heart meridian five shu points which restrains the dominant characteristic of assumed constitution. However, because sometimes the patient's personality, appearances, and response to acupoint needling are not typically fit into one specific constitution, it is not easy to identify one's constitution with those methods. As a solution, we can check epigastric tenderness and hepatic dullness sound before and after performing probable types of acupuncture on the patient. If you performed the correct type of acupuncture (your classification of the constitution was correct), epigastric tenderness and hepatic dullness get better after the treatment. Thus, epigastric tenderness and hepatic dullness can be diagnostic indices before the treatment as well as effect estimation indices during the course of treatment.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : There have been numerous psychological and psychiatric terms recorded in traditional Chinese medicine (TCM) bibliographies, developing a TCM specialty called mental-emotional diseases, where symptomatology, etiology, psychopathology, and various therapies are well established. Acupuncture and related therapies, such as acupressure, moxibustion, massage, cupping, scraping, psychological consultant, exercise therapy (e.g., tai-qi), meditation, and mindfulness were often used in the management of mental disease and wellbeing in early days. These therapies also have been increasingly introduced into today’s clinical practice of psychiatry, aiming to enhance the clinical efficacy, reduce side effects associated with conventional treatment, and comorbid symptoms. Over the past two decades, the speaker and other researchers have published a large number of clinical trials that have demonstrated the effectiveness of acupuncture in the treatment of insomnia, depression, anxiety, obsessive compulsive disorder (OCD), cognitive impairment, drug abuse, and psychotic disorders. Neuroimaging, neurochemical, and omic evidence further reveals the underlying mechanisms of psychotropic effects of acupuncture. This talk will provide an overview of ancient TCM psychological concepts and therapies, evidence-based findings obtained from preclinical and clinical studies, and the putative mechanisms of acupuncture effects in the treatment of psychological and mental diseases.

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objective Many studies demonstrated the efficacy of acupuncture in pain treatment. Different acupuncture techniques can be used to control pain (Traditional Acupuncture, Microsystems like ear, abdominal,scalp, etc.) and in resistant pain a combination of them can be more effective. Methods In this speech a novel approach to pain treatment, the Scalp-Luò technique,will be presented, with a combination of a specific technique of traditional acupuncture and scalp acupuncture. A practical demonstration will be held. Conclusions this simple but very effective approach could give a contribution in pain treatment, particularly in complicated cases that are resistant to traditional techniques.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Modern physics defines light as an electromagnetic radiation. As optical science reveals properties of the light, its medical applications are increasing. In the history of korean medicine, heliotherapy was used to promote vital energy. As written at Dongeuibogam, a concave mirror was used to get fire from solar light for moxibustion. Laser is a kind of light that is amplified by stimulated emission of radiation. It was suggested by Albert Einstien in 1920s. The first ruby laser was invented in 1960 by T. maiman. Monochromatic, coherent and collimated light is unique properties of laser radiation. Medical lasers can be classified as surgical laser and therapeutic laser. Surgical lasers has photo-thermal, photo-ablative and photo-chemical effects. Therapeutic lasers are focused on maximizing the photobiomodulation effects. It is a non-thermal process involving tissue chromophores eliciting ATP synthesis and modulating signal pathways. Photobiomudulation include pain relieving, anti-inflammatory, anti-edematous, wound healing and scar preventing effects. Korean medicine doctors are using artificial light source for acupuncture and moxibustion treatments. Several lasers are used to stimulate acupoints. Laser acupuncture is useful in the treatment of tendinitis, osteoarthritis, muscle pain. Transcranial laser therapy has been studied for brain injuries such as traumatic brain injury and stroke.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Goal Compare and analyze the indicators of clinical neurological examination, MRI, auricular, su-jok diagnosis in patients after a stroke and with chronic cerebrovascular disorder to further substantiate the use of complementary methods in clinical practice, primarily as an express method. Objectives and methods Group І-56 patients after a stroke in the early residual period, age 64 ± 7.1, including 23 men and 31 women. 48 (85.7%) patients had a stroke in the carotid vascular basin, 8 (14.3%) - in vertebral-basilar. Group II-30 patients with signs of chronic cerebrovascular disorders. All patients underwent clinical-neurological examination, MRI-examination, assessment of the condition of the auricula (skin and subcutaneous tissues) and the assessment of the distal phalanges of the thumbs and the hallux - their circumference at the level of the middle of the nail plate in mm was measured. All indicators were compared among each patient and I-II group indicators were compared with the data of 30 patients without vascular pathology of the brain. Results Clinical and neurological examination, which included the collection of complaints, anamnesis, the evaluation of objective indicators and MRI brain examination, verified the presence of a stroke and / or presence of chronic cerebrovascular disorders. All patients (100%) of first and second groups, regardless of gender and age, had trophic changes of varying degrees of severity in the area of the earlobe, ear antitragus, scaphoid fossa, posterior ear furrow, hypotrophy on both sides, more pronounced homolateral foci of a stroke, the presence of Frank's furrow, mesh in the form of shallow furrows, excoriations in the area of the anti-tragus. Compliance of the changes was observed depending on the localization of the stroke: shallow furrows with vertebro-basilar strokes in the upper part of the ear lobe, the carotid stroke - in the mid-lower part. In 62%, there was a sharp change in the color of the skin of the auricle at the level of the posterior auricle furrows and the edges of the earlobe (from red to ischemic pale). 83% had hypotrophy of the skin in the posterior auricle furrow, indicating vertebrogenic effects on cerebral dyscirculation. There were also sensitivity and trophic changes in the distal phalanxes of the thumb and the hallux compared by measuring at left and right in mm. Interestingly, the presence of stroke and chronic cerebral disorders without stroke was also accompanied by trophic and ischemic changes in the auricular and the thumb and the hallux, but differed significantly in the severity of manifestations, indicating the presence of precursors of strokes and the ability to predict them. These trophic changes were absent in patients without signs of cerebral circulation. Conclusions For the verification of vascular pathology of the brain and prediction of stroke, as well as the evaluation of the effectiveness of rehabilitation, it is advisable to use as a rapid-test auricular and su-joke diagnosis.

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats. Herein, we investigate molecular changes in colorectal cancer (CRC) rats by acupuncture treatment using the nanoporous needles. Treatment at acupoint HT7 is found most effective at reducing average tumor size, β-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Surface modification of acupuncture needles further enhances the therapeutic effects of acupuncture treatment in CRC rats.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objective To evaluate the effect of different reflexology techniques on main clinical indices of patients with chronic migraine, the number of analgesics used and dynamics of chronic migraine comorbid disorders. Material and methods The study included 84 patients (60 women (71.5%) and 24 men (28.5%)), aged from 18 to 63 years, with a diagnosis of chronic migraine. Patients were randomized in 4 groups - Su Jok (n = 22), acupuncture (n = 22), electroacupuncture (n = 20), control (n = 20). Topiramate was administered in all groups in dose of 100 mg daily. Patients were evaluated before treatment, after 4 and 16 weeks from randomization. Results There was a marked regression in frequency of headache in reflexological groups in comparison with the control. The number of days with headache was 19 ± 1.12 at baseline and 6.57 ± 1.3 days after treatment in the Su Jok group; 21.6 ± 1.688 and 7 ± 1.786 days in the acupuncture group; 20.25 ± 1.97 and 5.75 ± 0.633 days in the electroacupuncture group. Each of the methods had an impact on various clinical aspects of chronic migraine and comorbid disorders: Su Jok was most effective in treatment of autonomic disorders, the use of acupuncture resulted in the significant reduction of headache intensity and regression of anxiety disorders. The electroacupuncture group showed a significant increase in pain threshold and the least number of days with headache per month. Conclusion Reflexotherapy is a method of choice in the complex treatment of patients with chronic migraine. Taking into account complex diagnosis, the individually oriented approach in prescribing of different reflexology techniques for successful treatment and subsequent rehabilitation of patients with chronic migraine is required

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Journal Info

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
February, 2021
Vol.14 No.1

pISSN 2005-2901
eISSN 2093-8152

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  • Research Article2020-06-01

    Effectiveness of Manual and Electrical Acupuncture for Chronic Nonspecific Low Back Pain: A Randomized Controlled Trial

    Josielli Comachio 1, *, Carla C. Oliveira 1, Ilton F.R. Silva 1, Mauricio O. Magalhães 1, 2, Amélia P. Marques 1

    Abstract : Background: Low back pain is a common condition that can be effectively treated by acupuncture. However, several treatment point prescriptions and further electrical needle stimulation (i.e., local acupoints, distal acupoints, and sensitized acupoints) may be used. There is an implicit yet unexplored assumption about the evidence on manual and electrical stimulation techniques. Objective: The present study aims to identify effectiveness of electroacupuncture (EA) and manual acupuncture (MA) on pain and disability in patients with chronic nonspecific low back. Methods: This study is a randomized controlled clinical trial. Sixty-six patients between 20 and 60 years of age with non-specific chronic low back pain experiencing low back pain lasting for at least the previous three months and ≥3 points on a 10 numerical analogic scale. Patients diagnosed with chronic LBP were assigned to receive either 12 sessions of MA or EA. The primary outcomes measurements were pain intensity on Numeric Rating Scale and disability by Roland Morris Disability Questionnaire. Results: The participants reported improvements post-treatment to pain intensity and disability respectively; however, no differences between groups were observed. Regarding the secondary outcomes, we observed a between-group difference only for kinesiophobia in favor of the manual acupuncture group (difference = -4.1 points, 95% CI = -7.0 to -1.1). The results were maintained after 3 months of follow-up. Conclusion: The study provides evidence that EA is not superior to MA treatment. Both therapies had similar efficacy in reducing pain and disability for chronic nonspecific low back pain.

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  • Research Article2020-06-01

    Effect of Transcutaneous Electrical Nerve Stimulation on the Pain Intensity During Insertion of Needle in Patients Undergoing Spinal Anesthesia: A Randomized Controlled Study

    Javad AminiSaman 1, Hasan A. Karimpour 1, Behzad Hemmatpour 2, Saeed Mohammadi 1, Saeed Darvishi 3, Rasool Kawyannejad 4, 5, *

    Abstract : Background and objectives: Needle insertion pain during spinal anesthesia is an unpleasant experience for patients. This study aimed to investigate the effects of Transcutaneous Electrical Nerve Stimulation (TENS) on the pain intensity during the insertion of spinal needles in patients undergoing spinal anesthesia. Materials and methods: In a double-blind clinical trial, 60 candidates for elective Trans Ureteral Lithotripsy surgery under spinal anesthesia were randomly divided into intervention and control groups. The electrodes of the TENS device were placed in the space between L3-L4 and L5-S1 vertebrae. The intensity of pain during insertion of the spinal needle by Visual Analog Scale and the frequency of attempts were recorded. Results: The mean age of the study samples was 34.26 ± 5.07 and 32.8 ± 5.28 in the control and intervention group, respectively. The pain intensity during insertion of spinal needles was less significant in the intervention group compared to the control group (p = 0.001). The number of attempts to insert the spinal needle between the two groups was not statistically significant (p = 0.51). The duration of spinal anesthesia implementation procedure by physician in the intervention group was significantly shorter than that of the control group (p = 0.001). Conclusion: The use of TENS effectively reduced the pain of spinal needle insertion. Considering these beneficial effects, it is suggested that this procedure be used to relive pain in patients with spinal anesthesia.

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  • Research Article2020-10-01

    The Effect of Laser Acupuncture on Spasticity in Children with Spastic Cerebral Palsy

    Dian E. Putri 1, *, Adiningsih Srilestari 1, Kemas Abdurrohim 1, Irawan Mangunatmadja 2, Luh K. Wahyuni 3

    Abstract : Background: Spasticity in cerebral palsy is one of the most common disabilities of children in developing countries. Objectives: The objective of this study was to determine the efficacy of laser acupuncture on spasticity in children with spastic cerebral palsy. Methods: This clinical trial was conducted on 60 patients with spastic cerebral palsy at 2 to 10 years. The patients were categorized into two groups: the control group and treatment group. Laser acupuncture was applied on GV20, GV14, LI4, GB34, and LR3 (power 50 mW, 785 nm, 1 Joule, 40 seconds) three times a week for 12 sessions in the treatment group and placebo laser acupuncture on the same points in the control group. The spasticity was measured using the Modified Ashworth Scale before and after complete sessions. Results: The results showed that there was a significant reduction in the Modified Ashworth Scale score in the treatment group compared with the control group (p = 0.003). Conclusions: This study suggest that laser acupuncture on GV20, GV14, LI4, GB34, and LR3 can reduce spasticity for children with spastic cerebral palsy.

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  • Research Article2020-08-01

    Abstract : Background: Osteoarthritis is the most common type of arthritis. Depression, anxiety, and stress are associated with knee osteoarthritis. Objectives: The aim of the study was to check the effectiveness of acupressure therapy with pharmacological treatment on pain, depression, anxiety, and stress in patients with knee osteoarthritis and to assess the effect of pain improvement on psychological health. Methods: Eligible 212 patients with knee osteoarthritis were divided into two groups (intervention and control group). The intervention group (n = 106) received acupressure therapy in combination with pharmacological treatment, whereas the control group (n = 106) continued pharmacological treatment only. Pain and psychological symptoms were measured using the visual analog scale and Depression Anxiety Stress Scale-21. Pearson's correlation was used to check the effect of pain improvement on psychological health. Results: Patients of both groups reported severe pain initially. On analyzing the results after completion of the study, it was found that patients in the intervention group scored better on the pain scale (p < 0.001) and DASS-21 (p ≤ 0.0001). However, it may be noted that reduction in the DASS-21 score was not found to be significant for the control group (p = 0.08). Pearson's correlation coefficients value ranged from 0.231 to 0.412 for DASS-21 (p < 0.05). Conclusions: On analysis, it can be concluded that acupressure can be used as add-on therapy in combination with conventional treatment (pharmacological treatment), which may assist in pain reduction. The reduction in pain directly contributes to improvement in the physiological wellness among patients with knee osteoarthritis.

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Purpose As science and medicine evolves, the average life span of mankind is rapidly being extended. The growing population of the elderly and interest towards well-being is stimulating growth of the complementary medicine market. Acupuncture is one of the most popular treatments to the patients seeking complementary medicine. As patient population receiving acupuncture increases worldwide, needs for a standardized clinical guideline is growing. Among the many diseases treated by acupuncture, musculoskeletal disorders rank the top. The objective of this study is to establish Korean Medicine clinical guideline for non-specific chronic low back pain. Methods A task force team to establish the guideline was composed. Literature review was done in order to search for evidence of safety and efficacy of acupuncture and other Korean Medicine treatments. A survey was done in order to find out how Korean medical doctors derive pattern identification for acupuncture and herbal prescriptions in treating non-specific chronic low back pain. Then, based on the results of literature review and survey, a conference meeting of experts was held. Through the Delphi method, a draft of the acupuncture clinical guideline for non-specific chronic low back pain was established. Now the review board, composed of experts of musculoskeletal disorders, public health, statistics, and representatives of patients are modifying the draft. Results Evidence of safety and efficacy of acupuncture treatment for musculoskeletal disorders was established. A standard or pattern identification was derived. A draft of Korean Medicine clinical guideline for non-specific chronic low back pain was established. Conclusions More rigorous, well designed and large scaled RCTs are in need to improve the quality and make modifications this clinical guideline.

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Objectives This study is related to stimulate of mesenchymal stem cell (MSC) release into blood by use of electroacupuncture (EA) at specific acupoints. Methods EA was performed in rats using LI4, LI11, GV14, and Baihui (rats). Results Through some methods such as functional magnetic resonance imaging (fMRI) and pharmacological disinhibition of hypothalamus, the activation of the sympathetic nervous system resulted in a release of MSC into the circulation. In addition, EA treatment in rats that had partial rupture of the Achilles tendon induced analgesia, increasing interleukin-10 levels and remodeling. Conclusion EA as low risk, and very effective method should be used to support the repair of tissue wound by increasing of the circulating MSC.

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