전체메뉴
Search
Article Search

JoP

Most Downloaded

  • Abstract : The institute of Cannabis Research (ICR) was established in 2016 through a unique partnership between Colorado State University-Pueblo, the State of Colorado, and Pueblo County. The mission of the ICR is to generate new knowledge and understanding of cannabis through innovative research, education, and dissemination of results and information. This presentation will include background information on the ICR and its activities, a discussion of trends in cannabis research in the United States, and results from some research projects supported through the ICR. The first project focuses the development of an efficient extraction method for the recovery of the cannabinoid cannabidiol (CBD) from industrial hemp (< 0.3% Δ9-tetrahydrocannabinol) using pressurized liquid extraction (PLE). This unique PLE method includes a dual extraction process in which the hemp undergoes a pre-extraction with water to promote decarboxylation of cannabidiolic acid (CBD-A) to CBD, without significant loss of neutral cannabinoids, followed by PLE using ethanol to extract the CBD. This PLE method can be employed to efficiently carry out decarboxylation of other acidic cannabinoids to their neutral counterparts. A second project that will be discussed is an interrupted time series analysis was conducted to assess the impact of Colorado’s legalization of both medical (2000) and recreational (2014) cannabis over the time period 1999 - 2018. Both were associated with a reduction of opioid overdose mortality rates. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado. The final projects that will be discussed aim at showing mechanisms which underlie effects of various cannabinoids on learning and memory in a rodent model. Our published results have shown prominent effects of Cannabidiol on the fundamental mechanisms of learning and memory, and work in progress is showing similar effects of HU-211, a synthetic glutamate receptor inhibitor. This basic medical research involves behavioral, pharmacological, electrophysiological and histological methods and has relevance for understanding appropriate medical applications for cannabinoids to treat brain disorders ranging from Alzheimer’s disease to Post Traumatic Stress Disorder.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objectives Sasang Constitutional Medicine is uniquely established in the field of Korean Medicine and Eight Constitution Acupuncture which is created upon Sasang constitutional medicine is widely applied in clinics. However, there exist no established theory but hypotheses with regard to the composition of acupoints of constitution acupuncture. The purpose of this study was to compare the acupuncture method between Sasang Constitutional Medicine and Eight Constitution Medicine. Methods We reviewed a total of 11 studies found on various domestic Oriental medicine journals and 7 literature ect. with the key words of Sasang Acupuncture, Eight Constitution Acupuncture and acupoint. Results Among studies and literature chosen, the application of Saam’s acupucture method was many. Eight Constitution Medicine method is applied in the various disease and clinical studies were increased after the year 2000. Conclusion Although there were vulnerable approached to its theoretical and clinical evidence, further study should be followed to establish proper method of constitutional acupuncture.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : ALS , often referred to as “ Lou Gehring’s Disease,” is a progressive disorder that causes degeneration of the motor neurons in the spinal cord, brain stem, and motor cortex that control the voluntary muscle movement. The average ALS patient’s life span is less than three years from when symptoms first appear. Unfortunately ALS is progressive disease until death. The significant symptoms of ALS include muscle spasticity, muscle weakness, paralysis, fasciculation, impaired speaking, swallowing and breathing. Acupuncture treatments showed the high correlation with K-ALSFRS-R score and Sa-am acupuncture lung tonification. And Sa-am acupuncture lung tonification would be more effective on early stage of ALS disease. We found that Pharmacopuncture of Bee venom, Scolopendrid and Hominis Placenta attenuates neuroinflammatory events and extends survival in ALS models. We observed that Mecasin, a novel antineuroinflammatory Agent, inhibits neuroinflammatory responses and Mecasin exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation. According to analysis of clinical trial, the low dose or high dose mecasin group showed better results than the riluteck control group.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : While several studies have found that chronic pain is characterized by increased cross-network connectivity between salience, sensorimotor, and default mode (DMN) networks, a large sample-size investigation allowing a more reliable evaluation of somatotopic specificity and subgroup analyses with linkage to clinical pain intensity has been lacking. We enrolled healthy adults and a large cohort of patients (N=181) suffering from chronic low back pain (cLBP). To specifically link brain connectivity with clinical pain intensity, patients were scanned at baseline and after performing physical maneuvers that exacerbated pain. Compared to healthy adults, cLBP patients demonstrated increased connectivity between the functionally-localized back representation in primary somatosensory cortex (S1back) and both salience and DMN networks. Pain exacerbation maneuvers increased S1back connectivity to salience network regions, but decreased connectivity to DMN, with greater pain intensity increase associated with greater shifts in these connectivity patterns. Furthermore, only in cLBP patients reporting high pain catastrophizing, DMN connectivity was increased to a cardinal node of the salience network, anterior insula cortex, which was correlated with increased post-maneuver pain in this cLBP subgroup. Hence, increased information transfer between salience processing regions, particularly anterior insula, and DMN may be strongly influenced by pain catastrophizing. Increased information transfer between salience network and S1 likely plays an important role in shifting nociceptive afference away from self-referential processing, re-allocating attentional focus and affective coding of nociceptive afference from specific body areas. These results demonstrate S1 somatotopic specificity for cross-network connectivity in encoding clinical back pain, and moderating influence of catastrophizing for DMN/insula connectivity.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Healing is a complicated process. Theoretically, it may be made up of three components: the self-healing properties of the body (power of the human body), the non-specific effects of treatment (power of the mind), and the specific effect of physical or pharmacological intervention (power of medicine). The final outcome is the combination of all three components. In my talk, I will introduce 1) the role of the power of the mind in acupuncture and how to apply the power of the mind to enhance the therapeutic effects of treatment, 2) how the mind and body can interact to produce treatment effects using mindful movement (Tai Chi and Baduanjin) as examples, and 3) a novel example demonstrating the power of the mind through imagery and its potential role in pain management.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Fatigue is a common and debilitating late-term effect of breast cancer that is associated with poor sleep and decreased quality of life, yet therapies remain limited. Acupressure has reduced fatigue in previous small studies, but rigorous clinical trials are needed. Here we sought to investigate if 6 weeks of 2 types of self-administered acupressure improved fatigue, sleep, and quality of life vs usual care in breast cancer survivors and to determine if changes were sustained during a 4-week washout period. Our primary outcome was change in the Brief Fatigue Inventory score from baseline to weeks 6 and 10. Secondary analyses were sleep (Pittsburgh Sleep Quality Index) and quality of life (Long-Term Quality of Life Instrument). We enrolled a total of 424 survivors of stages 0 to III breast cancer who had completed cancer treatments at least 12 months previously were screened, and 288 were randomized, with 270 receiving relaxing acupressure (n = 94), stimulating acupressure (n = 90), or usual care (n = 86). At week 6, the percentages of participants who achieved normal fatigue levels (Brief Fatigue Inventory score < 4) were 66.2% (49 of 74) in relaxing acupressure, 60.9% (42 of 70) in stimulating acupressure, and 31.3% (26 of 84) in usual care. At week 10, a total of 56.3% (40 of 71) in relaxing acupressure, 60.9% (42 of 69) in stimulating acupressure, and 30.1% (25 of 83) in usual care continued to have normal fatigue. These effects were statistically significant and clinically relevant. At neither time point were the 2 acupressure groups significantly different. Relaxing acupressure, but not stimulating acupressure, also showed significant improvements in sleep quality compared with usual care at week 6, but not at week 10. Only relaxing acupressure significantly improved quality of life vs usual care at weeks 6 and 10. We conclude that both acupressure arms significantly reduced persistent fatigue compared with usual care, but only relaxing acupressure had significant effects on sleep quality and quality of life. Relaxing acupressure offers a possible low-cost option for managing symptoms in cancer survivors.

    Abstract
  • Research Article2020-04-08
    JAMS

    Abstract : Perimenopausal depression is caused by the impaired function of the ovarium before menopause and with a series of symptoms. Electroacupuncture (EA) therapy has been demonstrated to improve clinically depression. However, the mechanism underlying its therapeutic activity remains unknown. This study used chronic unpredictable mild stress (CUMS) combined with bilateral ovariectomy (OVX) to establish a rat model of perimenopausal depression, and investigated the effects of EA treatment on the hippocampal neural proliferation. Four-week EA treatment at three points including “Shenshu” (BL 23), “Baihui” (DU 20), and “Sanyinjiao” (SP 6) simultaneously ameliorated depression-like behaviors in rats with CUMS and OVX, whereas rescued the decreased serum level of estrogen (E2) and prevented the increased serum levels of gonadotropin-releasing hormone and luteinizing hormone. EA treatment ameliorated CUMS and OVX-induced alterations of glycogen synthase kinase-3β and β-catenin mRNA levels, β-catenin and phosphorylated β-catenin (p-β-catenin) protein levels. The results showed that EA treatment promoted hippocampal neural proliferation in perimenopausal depression rats via activating the Wnt/β-catenin signaling pathway, indicating that EA may represent an efficacious therapy for perimenopausal depression.

    Abstract
  • Research Article2020-03-26
    JAMS

    Effectiveness of manual and electrical needle stimulation in acupuncture for chronic nonspecific low back pain: a randomized controlled trial

    Josielli Comachio1*, Carla Coelho Oliveira1, Ilton Fagner Rodrigues Silva1, Mauricio Oliveira Magalhães21, Amélia Pasqual Marques1

    Abstract : AimThe aim of this study was to investigate effectiveness of electroacupuncture (EA) and manual acupuncture (MA) on pain and disability in patients with chronic low back.MethodsA total of 66 randomly allocated patients diagnosed with chronic LBP were assigned to receive either 12 sessions of acupuncture or electr LINK Word.Document.12 D:MYFILESELSEVIERJAMS00000470PREPTUDJAMS_470_tud.docx OLE_LINK1 a r Sao Paulooacupuncture. The primary outcomes measurements were intensity pain (NRS) and disability (RMQ). All main analysis followed the intention-to-treat principle.ResultsThe groups reported improvements posttreatment in intensity pain and disability respectively; however, no differences between groups were observed. Regarding the secondary outcomes, we observed a between-group difference only for kinesiophobia in favor of the manual acupuncture group (difference = −4.1 points, 95% CI = −7.0 to −1.1). The results were maintained after 3 months of follow-up. Contrary to our hypothesis, however, EA did not result in a better outcome compared with MA treatment.ConclusionThe study does not provide evidence that an electroacupuncture is superior to acupuncture treatment. Both therapies had similar efficacy in reducing pain and disability for chronic nonspecific low back pain.

    Abstract
  • Research Paper2019-10-01

    Stimulation of Bladder Acupoints by Cloprostenol for Treating Back Soreness in Athletic Horses

    Eldessouky Sheta1*, Haithem Farghali1, Safwat Ragab2, Nagwa Hassan3, Asmaa El-Sherif4

    Abstract : Twenty-five Thoroughbred jumper geldings suffered back soreness with poor performance, and 5 control horses were assessed by archived computer data, clinical examination, and laboratory analyses of complete blood picture, serum enzymes, and cortisol level, before and after cloprostenol-pharmacopuncture. The 25 diseased horses before therapy showed significant increases in aspartate aminotransferase and creatine phosphokinase with clinical pains scored mild in 15 horses, moderate in 9 horses, and severe in one horse, without changes in the hormonal and hematological data. After therapy, they responded by an increase of heart rate (57.8 ± 4.3 bpm), body temperature (38.5 ± 0.7°C), respiration rate (28.3 ± 2.1 bpm), and capillary refilling time (CRT) (1.0 ± 0.0). On the 2nd day, a significant decrease in the mean levels of aspartate aminotransferase and creatine phosphokinase (P = 0.001) was detected, while on the 4th day, they mimed the level of the 5 controls, and on the 6th day, they showed a significant decrease (P = 0.002). The serum cortisol level showed a significant increase on the 6th day of treatment (P = 0.013). The blood picture showed significant increases in red blood cells, mean corpuscular volume, platelets, white blood cells, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean platelet volume, platelet distribution width, lymphocytes, plateletcrit, and large platelet concentration ratio (P 

    Abstract

Journal Info

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
February, 2021
Vol.14 No.1

pISSN 2005-2901
eISSN 2093-8152

Archive >

Editorial Office

Most Read / Downloaded

  • Research Article2020-10-01

    Impact of Acupuncture Intervention on the Pain Intensity of Patients Treated at a Tertiary Hospital in Brazil

    Natália F. Valente 1, *, Eliezer de Sousa Cardoso 2, Juliana A. da Silva Rezende 2, Jeferson A. Santos 3

    Abstract : Background: Nowadays, in western societies, acupuncture is widely used over the control of pain and this analgesic approach is still the most studied aspect of acupuncture. Several studies have shown that most patients go through a significant pain decrease soon after the first sessions of acupuncture. Objectives: This research has as a goal the evaluation on the effect of acupuncture treatment regarding the relief of pain intensity of different etiologies, through the visual analog scale. Methods: This research constitutes a retrospective, descriptive study, carried out with 449 patients attended in the Institute Hospital de Base of the Federal District, in Brasilia citye Brazil. Every data was gathered from our own form, with detailed clinical history which included age, marital status, work activity, reason for referral to acupuncture, main and secondary complaints, pain intensity evaluated by the Visual Analog Scale (VAS), number of sessions completed and drug therapy. All data was organized in the Microsoft Excel and processed in the Statistical Package for the Social Sciences (SPSS), version 20.0. Results: Regarding the main complaint, the mean pain decreased from 7.3 (initial VAS) to 3.2 (final VAS), a reduction that meant more than 50% relief in pain intensity. This 50% reduction in initial pain was also observed in secondary complaints (initial VAS = 6.5 and final VAS = 3.1). Conclusions: The results of this research suggest that acupuncture treatment was effective in relieving pain intensity, providing a 50% reduction on the visual analogue scale, in relation to painful complaints of different etiologies.

    Abstract
  • Research Article2020-04-01

    Abstract : The prevalence of elderly dementia and work-related back neck pain is high, and so is the associated cost. Is dementia, which can take 20–30 years to develop, linked to musculoskeletal problems earlier in life? Classic Chinese Medicine Governor Vessel (GV) theory has in fact detailed a correlation, but its acceptance appears to be influenced and even limited by some inconsistences in the literature. This study involved a nationwide online questionnaire of 381 practicing acupuncturists to investigate GV's usage and impact on brain function. The survey covers areas of the acupuncturist's experience, perception of GV usage, related symptoms, needling concerns and correlations with brain function. 39 completed questionnaires were returned, of which 38 were GV users, and nearly three quarters of respondents accepted that GV influences brain function. Only two respondents rejected this influence, but here several inconsistencies were found. The associations with GV were predominately found to be with the spine, kidney, and brain. Indications from practitioners suggested numerous forms of clinical usage of GV, predominately on spinal, cognitive and qi-blood movement issues. GV influence on the brain was accepted by most respondents with only a few expressing uncertainty. Further worldwide, larger population, in-depth studies and trials are needed to fully establish and expand upon these findings.

    Abstract
  • Research Paper2019-08-01

    Effects of Acupressure on Fatigue in Patients with Cancer Who Underwent Chemotherapy

    Atefeh Ghanbari Khanghah1, Moloud Sharifi Rizi2*, Bahram Naderi Nabi3, Masoumeh Adib4, Ehsan Kazem Nejad Leili5

    Abstract : Fatigue is the commonest symptom in cancer patients; despite high levels of clinically significant persistent cancer-related fatigue, few treatments are currently available. The aim of this study was to evaluate the efficacy of acupressure on fatigue in patients with cancer who underwent chemotherapy. The study was designed as a randomized and controlled trial. Ninety samples were selected using the convenience sampling method, and random block sampling was used for allocation of groups (30 for each group). The three groups were similar by age and gender. The experimental group underwent acupressure at the Zusanli (ST-36), Hegu (LI-4), and Sanyingjiao (SP-6), whereas sham pressure was used in the placebo group and no intervention was applied in the control group; the level of fatigue of participants in three groups was calculated in three phases, before, during, and after chemotherapy. Data were analyzed using SPSS, version 22. The results showed that the mean of visual analog score of fatigue is significantly different in three groups at the end of chemotherapy (p = 0.021). The mean visual analog score of fatigue in the acupressure group was meaningfully lower than that in the control group after chemotherapy (p = 0.028). Results of this investigation showed that acupressure has short-term effectiveness on the cancer-related fatigue of patients undergoing chemotherapy.

    Abstract
All Newest Articles
  • Erratum2020-12-01
  • Research Article2020-10-01

    Impact of Acupuncture Intervention on the Pain Intensity of Patients Treated at a Tertiary Hospital in Brazil

    Natália F. Valente 1, *, Eliezer de Sousa Cardoso 2, Juliana A. da Silva Rezende 2, Jeferson A. Santos 3

    Abstract : Background: Nowadays, in western societies, acupuncture is widely used over the control of pain and this analgesic approach is still the most studied aspect of acupuncture. Several studies have shown that most patients go through a significant pain decrease soon after the first sessions of acupuncture. Objectives: This research has as a goal the evaluation on the effect of acupuncture treatment regarding the relief of pain intensity of different etiologies, through the visual analog scale. Methods: This research constitutes a retrospective, descriptive study, carried out with 449 patients attended in the Institute Hospital de Base of the Federal District, in Brasilia citye Brazil. Every data was gathered from our own form, with detailed clinical history which included age, marital status, work activity, reason for referral to acupuncture, main and secondary complaints, pain intensity evaluated by the Visual Analog Scale (VAS), number of sessions completed and drug therapy. All data was organized in the Microsoft Excel and processed in the Statistical Package for the Social Sciences (SPSS), version 20.0. Results: Regarding the main complaint, the mean pain decreased from 7.3 (initial VAS) to 3.2 (final VAS), a reduction that meant more than 50% relief in pain intensity. This 50% reduction in initial pain was also observed in secondary complaints (initial VAS = 6.5 and final VAS = 3.1). Conclusions: The results of this research suggest that acupuncture treatment was effective in relieving pain intensity, providing a 50% reduction on the visual analogue scale, in relation to painful complaints of different etiologies.

    Abstract
  • Case Report2019-06-01

    Concurrent Effects of Dry Needling and Electrical Stimulation in the Management of Upper Extremity Hemiparesis

    Maryam S. Ghaffari1, Ardalan Shariat1*, Roshanak Honarpishe2, Azadeh Hakakzadeh1, Joshua A. Cleland3, Sepehr Haghighi4, Tohid S. Barghi1

    Abstract : Stroke is one of the leading causes of disability in western countries. A variety of rehabilitation programs for the treatment of patients after stroke have been proposed. We describe the outcomes of a 49-year-old female patient with a 5-year history of right upper extremity hemiparesis after stroke. Physical examination revealed a right wrist extensor strength grade of 1 according to the Medical Research Council Manual Muscle Testing scale, Stage 4 according to the Brunnstrom hand functional recovery, and Grade 1 in finger flexor and in wrist flexor according to the Modified Modified Ashworth Scale system of muscle spasticity. Magnetic resonance imaging taken immediately after the stroke was indicative of an abnormal signal in the left paraventricular and lentiform nucleus. After receiving a single session of dry needling and electrical stimulation, the patient had significant improvement including a strength grade of 3 for the right wrist extensor muscles, Stage 6 according to the Brunnstrom hand functional recovery, and Grade 0 in finger flexor and in wrist flexor according to the Modified Modified Ashworth Scale system of muscle spasticity. This case report found that dry needling combined with electrical stimulation may be effective in hand function recovery, wrist extensor muscles strength, and decreased wrist and finger spasticity.

    Abstract
All Newest Articles

Scimago Journal & Country Rank

SCImago Journal & Country Rank