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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Glandular trichomes are known to be the sites of cannabinoid accumulation in Cannabis sativa. They cover the surface of the aboveground plant parts but are most abundant on the floral bracts of pistillate plants. This study conducted to determine where the cannabinoids are synthesized and localized at the whole-plant level and at the cellular level using micromanipulation and transmission electron microscopy. According to their external features, three types of glandular trichomes are recognized: bulbous, capitate-sessile, and capitate-stalked trichomes. The gland head consist of disc cells containing cytoplasm and a non-cellular intrawall secretory cavity. The lipoplasts in the disc cells of globose heads synthesize lipophilic terpenes that migrate through the plasma membrane and into the cell wall adjacent to the secretory cavity. They subsequently pass through the cell wall and accumulate in the secretory cavity in the form of secretory vesicles. Numerous vesicles of different sizes and densities are localized in the secretory cavity. In conclusion, lipophilic terpenes and phenols, when released from their respective lipoplasts and vacuole compartments, accumulate in the plasma membrane/cell wall interface, where enzymes combine these precursors into cannabinoids. Mature glands possess the highest concentration of major cannabinoids, such as CBD in the fiber strains and THC in the drug strains of Cannabis sativa.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objectives This study was designed to analyze the usage of medical service support in Korean Medicine Clinic at the polyclinic during 2019 FINA world championships period for furthermore study. Methods We recorded the daily occurrence of injury and illness through the electrical medical record used in Korean Medicine Clinic arranged in the polyclinic at Athletes’ Village during the period of 2019 FINA world championships. Results Among the 3080 cases reported at the polyclinic from July 5th to 29th in 2019, 1135 cases were treated in Korean Medicine clinic and this is about 36.8% of all the cases, the leading percentage in the polyclinic. In 1135 cases, the category of athletes were 509 cases (44.8%), the category of team officials were 221 cases (19.4%) and the category of FINA family were 92 cases (8.1%). Nationality of Russia was the most with 72 cases, and nationality of Republic of South Africa was the 2nd most with 69 cases. Respectively the ratio of injury among the patient visited the clinic was 89% (n = 1010), and the illness was 10.6% (n = 120). Respectively 48% of people (n = 543) who visited the clinic had an experience of acupuncture treatment before and 52% (n = 592) of people never experienced before. The frequency of treatment method used in the clinic was chuna manual medicine (64%), acupuncture (64%), and cupping (16%) in order. The frequency in location of body part treated was body trunk (n = 516, 49%), lower limbs (n = 205, 18%), upper limbs (n = 145, 12.8%) and head & neck (n = 93, 8.2%) in order. Conclusions The clinic using acupuncture established inside the polyclinic during the sports events hosted by the Federation Internationale de Natation was the first time ever in 2019 world championships. So the presented data constitute the basis for future analysis and study. Korean Medicine is likely to be effective in terms of the medical assistance for the international sports level of athletes, however further study is needed.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : In many countries, researchers and administrators have struggled to apply a standardized data model to harmonize and collect medical data from a variety of heterogeneous sources. However, various barriers exist such as system heterogeneity, various data formats, changes in human protection rules around the world, trust building, contracting and coordination, and research governance policies. Recently, Distributed Research Network (DRN) such as Observational Health Data and Informatics (OHDSI, pronounced “Odyssey”) has gained popularity among clinical data partners worldwide. DRN uses the same data structure, called the Common Data Model (CDM), to run the same analysis program for participating organizations and then combine the results summarized over the network to provide results across the network. OHDSI has transformed more than 1.9 billion patient data from 99 databases in 19 countries into the OMOP (Observational Medical Outcomes Partnership) CDM format. Korean government supports OHDSI by providing research grants to more than 30 projects on CDM (2018-2022) with total budget of 40M USD. The author oversees FEEDER-NET (Federated E-health Big Data for Evidence Renovation Network), a 3-year research project (2018-2020) granted from government. The total budget of the project is about 10M USD. He is also in charge of new FEEDER-NET+, a new 4-year research project (2019-2022) granted from government. The total budget of this project is about 10M USD. Sixty-one largest Korean hospitals joined the FEEDERNET and FEEDER-NET+. By the end of 2019, more than 25M Korean patient data from EMR are expected to be available in CDM, and the whole Korean population data from EMR and claim data are expected to be available within 3 years. The author will present how the OHDSI became popular in Korea, and where the Korean clinical society moves forward through the CDM. In his talk, he will also demonstrate how OHDSI will enable researchers to access a network of billions of patients to generate evidence about all aspects of healthcare.

    Abstract
  • Case Report2019-12-01

    Abstract : Cervicogenic somatic tinnitus is a subtype of subjective tinnitus and is defined as tinnitus in which forceful contractions of jaw and neck muscles modulate its psychoacoustic attributes. Various physical therapies have been proposed for the treatment of somatosensory tinnitus although there is no definitive cure for it. This report describes the use of acupuncture in the treatment of a 71-year-old woman with chronic neck pain who suffered from a left-sided tinnitus for 2 years as well. The tinnitus and neck pain severity was rated as 7 and 6, respectively, on a numeric rating scale of 10. On examination, she had restricted cervical range of motion and several myofascial trigger points in cervical muscles. Audiometric tests of the patient were normal. She received trigger point acupuncture of cervical muscles twice per week for 10 sessions. Her tinnitus completely disappeared after the third session and did not return during the 5-year follow-up. Her neck pain intensity also decreased to 1 on the numeric rating scale after 10 sessions. Based on the results of this study, direct trigger point acupuncture of cervical muscles may be beneficial in the treatment of somatic tinnitus with a long-duration effect.

    Abstract

Journal Info

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
February, 2021
Vol.14 No.1

pISSN 2005-2901
eISSN 2093-8152

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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Essential hypertension a multifactorial pathophysiological condition involves many systems including the sympathetic nervous system. Increased sympathetic activity contributes to the elevation of blood pressure during sympathoexcitatory cardiovascular reflex responses as well as in hypertension. We have shown that electroacupuncture (EA) reduces sympathoexcitation and both reflex elevations of blood pressure and hypertension in animals and humans. In addition, EA reduces sympathoexcitatory blood pressure responses in hypertensive subjects. Elevated blood pressure also is reduced with manual acupuncture and moxibustion. Hypothalamic to medullary cardiovascular regions in the brain process the actions of EA, manual acupuncture and moxibustion involving specific mechanisms during sympathoexcitation. Recent investigations focused on the peripheral mechanisms at the acupoint site during EA, manual acupuncture and moxibustion. We hypothesized that the transient receptor potential vanilloid (TRPV1) peripheral local mechanism at the acupoint site is involved in the blood pressure lowering effect. In anesthetized rats using neurophysiology, siRNA, pharmacology, immunohistochemistry and hemodynamic responses, our data show that peripheral local TRPV1 participates during the blood pressure lowering effect with manual acupuncture and heat sensitive moxibustion but not EA. Mechano sensitive TRPV1 contributes to manual acupuncture activating peripheral somatosensory nerves. In contrast, EA-induced increase of somatosensory activity is not affected by blockade of TRPV1 at the site of acupoint. Similarly, TRPV1 knockdown in dorsal root ganglia (DRG) reduced activation of the peripheral DRG neurons during manual acupuncture but not EA. Sympathoexcitatory increase in blood pressure is reduced by acupoint specific moxibustion through local heat sensitive TRPV1 but not EA. In aggregate, EA, manual acupuncture and moxibustion applied at specific acupoints employ different peripheral local mechanisms to reduce elevated blood pressure and over-excitation of sympathetic activity.

    Abstract
  • Case Report2020-04-01

    Abstract : Headache disorders are burdensome, both in terms of the number of people they affect, and in terms of associated healthcare spending. This report presents a 36-year-old female admitted to a tertiary university hospital with a primary complaint of intractable headache, caused by a combination of medication overuse headache, and headache secondary to aseptic meningitis. During her hospital stay, opioid analgesic doses were initially increased without success in an attempt to control her headache. Despite multiple medication trials the patient's headache failed to improve. On day ten of her hospitalization, she underwent a thirty-minute acupuncture session which resulted in immediate relief of her headache. She received one more acupuncture treatment the following day and was discharged to an acute inpatient rehabilitation facility on a vastly reduced dose of opioids. Instructions on how to taper the remaining opioids were provided, and the patient was scheduled for outpatient acupuncture therapy sessions for further headache management. This report demonstrates the importance of recognizing acupuncture as a viable treatment option for medication overuse headache and for headache secondary to systemic diseases such as aseptic meningitis. Furthermore, acupuncture should also be considered as a nonpharmacological modality to be used when tapering a patient off of high doses of opioids.

    Abstract
  • Research Article2020-06-01

    Electroacupuncture Promotes Neural Proliferation in Hippocampus of Perimenopausal Depression Rats via Wnt/β-Catenin Signaling Pathway

    Qin Jing , Lu Ren*, †, Xue Deng, Nan Zhang, Martin Fu, Ge Wang, Xi-Rong Jiang, Shu-Ru Lin, Cai-Rong Ming

    Abstract : Background and Objective: Perimenopausal depression is caused by the impaired function of the ovarium before menopause and with a series of symptoms. Electroacupuncture (EA) therapy has been demonstrated to improve clinically depression. However, the mechanism underlying its therapeutic activity remains unknown. This study aimed to investigat the effects of EA treatment on the hippocampal neural proliferation through Wnt signaling pathway. Methods: Chronic unpredictable mild stress (CUMS) combined with bilateral ovariectomy (OVX) were used to establish a rat model of perimenopausal depression. The open field test (OFT) and sucrose preference test (SPT) were used to assess depression-like behaviors in rats. ELISAs were used to measure estrogen (E2), luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels in the serum. RT-PCR and Western blot assay were utilized for measuring the mRNA expressions and protein expressions of GSK-3β/β-catenin. Results: Four-week EA treatment at three points including “Shenshu” (BL23), “Baihui” (GV20) and “Sanyinjiao” (SP6) simultaneously ameliorated depression-like behaviors in rats with CUMS and OVX, whereas rescued the decreased serum level of E2 and prevented the increased serum levels of GnRH and LH. EA treatment ameliorated CUMS and OVX-induced alterations of glycogen synthase kinase-3b (GSK3b) and β-catenin mRNA levels, β-catenin and phosphorylated β-catenin (p-β-catenin) protein levels. Conclusions: The results showed that EA treatment promoted hippocampal neural proliferation in perimenopausal depression rats via activating the Wnt/β-catenin signaling pathway, indicating that EA may represent an efficacious therapy for perimenopausal depression.

    Abstract
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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : The institute of Cannabis Research (ICR) was established in 2016 through a unique partnership between Colorado State University-Pueblo, the State of Colorado, and Pueblo County. The mission of the ICR is to generate new knowledge and understanding of cannabis through innovative research, education, and dissemination of results and information. This presentation will include background information on the ICR and its activities, a discussion of trends in cannabis research in the United States, and results from some research projects supported through the ICR. The first project focuses the development of an efficient extraction method for the recovery of the cannabinoid cannabidiol (CBD) from industrial hemp (< 0.3% Δ9-tetrahydrocannabinol) using pressurized liquid extraction (PLE). This unique PLE method includes a dual extraction process in which the hemp undergoes a pre-extraction with water to promote decarboxylation of cannabidiolic acid (CBD-A) to CBD, without significant loss of neutral cannabinoids, followed by PLE using ethanol to extract the CBD. This PLE method can be employed to efficiently carry out decarboxylation of other acidic cannabinoids to their neutral counterparts. A second project that will be discussed is an interrupted time series analysis was conducted to assess the impact of Colorado’s legalization of both medical (2000) and recreational (2014) cannabis over the time period 1999 - 2018. Both were associated with a reduction of opioid overdose mortality rates. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado. The final projects that will be discussed aim at showing mechanisms which underlie effects of various cannabinoids on learning and memory in a rodent model. Our published results have shown prominent effects of Cannabidiol on the fundamental mechanisms of learning and memory, and work in progress is showing similar effects of HU-211, a synthetic glutamate receptor inhibitor. This basic medical research involves behavioral, pharmacological, electrophysiological and histological methods and has relevance for understanding appropriate medical applications for cannabinoids to treat brain disorders ranging from Alzheimer’s disease to Post Traumatic Stress Disorder.

    Abstract
  • 2020-04-01
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Objectives Sasang Constitutional Medicine is uniquely established in the field of Korean Medicine and Eight Constitution Acupuncture which is created upon Sasang constitutional medicine is widely applied in clinics. However, there exist no established theory but hypotheses with regard to the composition of acupoints of constitution acupuncture. The purpose of this study was to compare the acupuncture method between Sasang Constitutional Medicine and Eight Constitution Medicine. Methods We reviewed a total of 11 studies found on various domestic Oriental medicine journals and 7 literature ect. with the key words of Sasang Acupuncture, Eight Constitution Acupuncture and acupoint. Results Among studies and literature chosen, the application of Saam’s acupucture method was many. Eight Constitution Medicine method is applied in the various disease and clinical studies were increased after the year 2000. Conclusion Although there were vulnerable approached to its theoretical and clinical evidence, further study should be followed to establish proper method of constitutional acupuncture.

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