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  • Review Article2019-04-01

    Acupuncture for the Treatment of Cardiovascular Diseases: A Systematic Review

    Rodrigo de Lima Pimentel1, Alice P. Duque1, Beatriz R. Moreira2, Luiz F. Rodrigues Junior12*

    Abstract : Acupuncture, for the westerns countries, is an innovative and low-cost therapy for treatment and prevention of cardiovascular diseases (CVDs). However, most of its effects and mechanisms are poorly understood. Thus, the objective of this work was to systematically review the literature regarding the clinical effects of acupuncture for the treatment and prevention of CVDs. A search for papers published in English or Portuguese in the past 20 years was conducted at PubMed, SciELO, and PEDro databases. Clinical trials conducted on the effects of acupuncture were included in this review. Two reviewers extracted the data independently from the remaining 17 articles after screening. The most used acupoint was PC6 (10 studies, 64.7%), followed by ST36 (6 studies, 35.3%) and auricular acupoints (4 studies, 23.5%). Among the clinical applications, hypertension was the most studied CVD, with acupuncture being the most reported method among the studies (70.6%). Only three articles reported no benefit in the treatment of CVDs for the methodology used. We conclude that although several studies indicated an improvement in the response of the cardiovascular system in CVDs by acupuncture, electroacupuncture, or electrostimulation treatment, the heterogeneity of the studies does not allow a standardization of its application for each specific disease, making further studies necessary for its use to become a reality.

    Abstract
  • Abstract : Background: Pain is a major complaint in cancer patients and a global problem that requires medical attention, including pain in cervical cancer. Although pharmacotherapy has been used for the treatment of cancer pain, there are still around 40% cannot be treated only with pharmacotherapy. Objectives: To determine the effects of electroacupuncture (EA) on pain in stage III cervical cancer patients. Methods: Twenty-eight stage III cervical cancer patients were divided into two groups (14 treatments and 14 controls) with randomized control trial design. The treatment group received EA with a frequency of 2/20-25 Hz at points of ST36, SP6, LI4 and LR3 for 30 minutes, while the control group did not receive EA. Both groups were given paracetamol and codeine at the same dose. Assessment was carried out by measuring pain scale (VAS), plasma β-endorphin levels, and quality of life/QoL (EORTC QLQ-C30) before and after therapy. Results: The average reduction in VAS in the treatment group (2.71 ± 1.14) compared to the control group (0.71 ± 1.33; p < 0.001), average increase in plasma β-endorphin levels in the treatment group (88.57 ± 52.46 pg/ml) compared to the control group (12.86 ± 56.76 pg/ml; p = 0.001), and in QoL, there were significant differences in symptom improvement between the treatment and control groups in the domain of fatigue, pain, insomnia and overall QoL (p < 0.05). Conclusion: Medical therapy combined with EA decreased pain scale, increased plasma β-endorphin levels, and improved the QoL for stage III cervical cancer patients.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objective Many studies demonstrated the efficacy of acupuncture in pain treatment. Different acupuncture techniques can be used to control pain (Traditional Acupuncture, Microsystems like ear, abdominal,scalp, etc.) and in resistant pain a combination of them can be more effective. Methods In this speech a novel approach to pain treatment, the Scalp-Luò technique,will be presented, with a combination of a specific technique of traditional acupuncture and scalp acupuncture. A practical demonstration will be held. Conclusions this simple but very effective approach could give a contribution in pain treatment, particularly in complicated cases that are resistant to traditional techniques.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Modern physics defines light as an electromagnetic radiation. As optical science reveals properties of the light, its medical applications are increasing. In the history of korean medicine, heliotherapy was used to promote vital energy. As written at Dongeuibogam, a concave mirror was used to get fire from solar light for moxibustion. Laser is a kind of light that is amplified by stimulated emission of radiation. It was suggested by Albert Einstien in 1920s. The first ruby laser was invented in 1960 by T. maiman. Monochromatic, coherent and collimated light is unique properties of laser radiation. Medical lasers can be classified as surgical laser and therapeutic laser. Surgical lasers has photo-thermal, photo-ablative and photo-chemical effects. Therapeutic lasers are focused on maximizing the photobiomodulation effects. It is a non-thermal process involving tissue chromophores eliciting ATP synthesis and modulating signal pathways. Photobiomudulation include pain relieving, anti-inflammatory, anti-edematous, wound healing and scar preventing effects. Korean medicine doctors are using artificial light source for acupuncture and moxibustion treatments. Several lasers are used to stimulate acupoints. Laser acupuncture is useful in the treatment of tendinitis, osteoarthritis, muscle pain. Transcranial laser therapy has been studied for brain injuries such as traumatic brain injury and stroke.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Background and Aim Cordycepin, the major active component from Cordyceps militaris, has been reported to significantly inhibit some types of cancer; however, its effects on ovarian cancer are still not well understood. In this study, we treated human ovarian cancer cells with different doses of cordycepin and found that it dose-dependently reduced ovarian cancer cell viability, based on Cell counting kit-8 reagent. Method and Result Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited β-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas β-catenin overexpression abolished the effects of cordycepin on cell death and proliferation. Furthermore, we found that Dkk1 overexpression by transfection downregulated the expression of c-Myc and cyclin D1. siRNA-mediated Dkk1 silencing downregulated the expression of Atg8, beclin, and LC3 and promoted β-catenin translocation from the cytoplasm into the nucleus. Conclusion These results suggest that cordycepin inhibits ovarian cancer cell growth, possibly through coordinated autophagy and Dkk1/β-catenin signaling. Taken together, our findings provide new insights into the treatment of ovarian cancer using cordycepin.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01
    JAMS

    Abstract : Objective To confirm the exact clinical efficacy of comprehensive treatment of advanced Non-Small Cell Lung Cancer (NSCLC) with Traditional Chinese Medicine (TCM), and to explore the clinical research methods of TCM oncology. Method In this study, 542 patients with advanced non-small cell lung cancer (III A-IV) were enrolled in a large sample, multi-center and prospective cohort study, including 260 patients in the Western Medicine cohort, 114 patients in the Chinese Medicine cohort and 168 patients in the Integrated Chinese and Western Medicine cohort. With PFS, OS and quality of life as the main indicators, the efficacy of comprehensive treatment of traditional Chinese medicine and its predominant population were observed. Result The median survival time was 280 days in the TCM cohort, 381 days in the western medicine cohort, and 465 days in the integrated traditional Chinese and Western medicine cohort. The difference between any two cohort groups was statistically significant (p < 0.0167). It indicated that the median survival time of the Chinese and Western combined cohort was the longest, followed by the western medicine cohort, and the Chinese medicine cohort was the shortest. The median progression-free survival time was 170 days in the TCM cohort, 180 days in the western medicine cohort, and 217 days in the integrated Chinese and Western medicine cohort. There was no statistically significant difference between Chinese medicine cohort and Western medicine cohort. There was statistically significant (p < 0.0167) difference between the TCM cohort and the integrated Chinese and Western medicine cohort. Although the difference between the western medicine cohort and the integrated Chinese and Western medicine cohort was not statistically significant, the results showed that the integrated Chinese and Western medicine cohort had a trend of improving the progression-free survival time compared with the western medicine cohort. The 1-year survival rate was 41% in the TCM cohort, 53% in the western medicine cohort, and 61% in the integrated Chinese and western medicine cohort. The 2-year survival rate was 26% in the western medicine cohort and 35% in the integrative medicine cohort. Conclusion According to the different stages of treatment, choosing the appropriate Chinese herbal medicine treatment can improve the physical condition, clinical symptoms, quality of life, reduce the adverse reactions of digestive tract caused by radiotherapy and chemotherapy for patients with advanced non-surgical lung cancer. It has the effect trend of enhancing the curative effect of radiotherapy and chemotherapy, and can prolong the survival time. Traditional Chinese medicine alone is not inferior to western medicine in disease progression and overall survival, and there are no obvious adverse reactions. Patients with advanced non-small cell lung cancer should be treated with integrated traditional Chinese and Western medicine when conditions permit. Patients with older age and poor physical condition can choose traditional Chinese medicine alone as appropriate.

    Abstract

Journal Info

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
February, 2021
Vol.14 No.1

pISSN 2005-2901
eISSN 2093-8152

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  • Case Report2020-04-01

    Abstract : Headache disorders are burdensome, both in terms of the number of people they affect, and in terms of associated healthcare spending. This report presents a 36-year-old female admitted to a tertiary university hospital with a primary complaint of intractable headache, caused by a combination of medication overuse headache, and headache secondary to aseptic meningitis. During her hospital stay, opioid analgesic doses were initially increased without success in an attempt to control her headache. Despite multiple medication trials the patient's headache failed to improve. On day ten of her hospitalization, she underwent a thirty-minute acupuncture session which resulted in immediate relief of her headache. She received one more acupuncture treatment the following day and was discharged to an acute inpatient rehabilitation facility on a vastly reduced dose of opioids. Instructions on how to taper the remaining opioids were provided, and the patient was scheduled for outpatient acupuncture therapy sessions for further headache management. This report demonstrates the importance of recognizing acupuncture as a viable treatment option for medication overuse headache and for headache secondary to systemic diseases such as aseptic meningitis. Furthermore, acupuncture should also be considered as a nonpharmacological modality to be used when tapering a patient off of high doses of opioids.

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  • Research Article2020-06-01

    Electroacupuncture Promotes Neural Proliferation in Hippocampus of Perimenopausal Depression Rats via Wnt/β-Catenin Signaling Pathway

    Qin Jing , Lu Ren*, †, Xue Deng, Nan Zhang, Martin Fu, Ge Wang, Xi-Rong Jiang, Shu-Ru Lin, Cai-Rong Ming

    Abstract : Background and Objective: Perimenopausal depression is caused by the impaired function of the ovarium before menopause and with a series of symptoms. Electroacupuncture (EA) therapy has been demonstrated to improve clinically depression. However, the mechanism underlying its therapeutic activity remains unknown. This study aimed to investigat the effects of EA treatment on the hippocampal neural proliferation through Wnt signaling pathway. Methods: Chronic unpredictable mild stress (CUMS) combined with bilateral ovariectomy (OVX) were used to establish a rat model of perimenopausal depression. The open field test (OFT) and sucrose preference test (SPT) were used to assess depression-like behaviors in rats. ELISAs were used to measure estrogen (E2), luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels in the serum. RT-PCR and Western blot assay were utilized for measuring the mRNA expressions and protein expressions of GSK-3β/β-catenin. Results: Four-week EA treatment at three points including “Shenshu” (BL23), “Baihui” (GV20) and “Sanyinjiao” (SP6) simultaneously ameliorated depression-like behaviors in rats with CUMS and OVX, whereas rescued the decreased serum level of E2 and prevented the increased serum levels of GnRH and LH. EA treatment ameliorated CUMS and OVX-induced alterations of glycogen synthase kinase-3b (GSK3b) and β-catenin mRNA levels, β-catenin and phosphorylated β-catenin (p-β-catenin) protein levels. Conclusions: The results showed that EA treatment promoted hippocampal neural proliferation in perimenopausal depression rats via activating the Wnt/β-catenin signaling pathway, indicating that EA may represent an efficacious therapy for perimenopausal depression.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Objectives Knee pain is the illness that has ranked top in the medical cost and visit number in the Korean Medicine (KM) institutions. With the trend that the older aged population is increasing, it is predicted that people with knee pain is increasing resulting in the life quality degradation and the high social costs. In this situation, KM has strength in the clinical practice of knee pain. The purpose of Clinical Practice Guideline (CPG) was to enhance the reliability of KM by reinforcing the evidence with objective and rational verification, to develop a standardized clinical guideline, and to make a reasonable judgment in the treatment of knee pain. Methods We assembled committee with experts and established development plan. Committee set up key questions and searched relevant evidence comprehensively by using following databases: Pubmed, Ovid-EMBASE, Cochrane library, CNKI, OASIS, and NDSL. The evidence were reviewed according to the pre-defined selection/exclusion criteria, and the guideline draft was made by using the quality of evidence (4 levels: High, Moderate, Low, and Insufficient) and the grade of recommendation (5 grades: A, B, C, D, and GPP) based on the GRADE method. Official consensus was obtained through the following steps: 1) we used the Delphi method to reach agreement on the draft. 2) draft was further revised through external review and produced into the final guideline. 3) guideline obtained confirmation from relevant academic societies. Results We classified knee pain into 4 categories (knee osteoarthritis, knee rheumatoid arthritis, soft tissue injury, and other type) and made guideline according to several KM treatments (e.g. manual acupuncture, electroacupuncture, warm or fire needle acupuncture, moxibustion, herbal medicine, pharmacopuncture, acuputomy, cupping, and others). Among them, it was confirmed that pharmacopuncture had moderate evidence and B recommendation level (high considerable) on knee osteoarthritis. To complement the existing CPG published in 2017, we will expand KM treatments (e.g. physiotherapy, chuna, and manipulation therapy), focus on the disease name (e.g. knee osteoarthritis not knee pain), and create evidence through direct execution of randomized clinical trial. Conclusion CPG is expected to provide objectivity, rationality, and standard of KM treatment for knee pain by continuous research and supplementation.

    Abstract
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  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : The institute of Cannabis Research (ICR) was established in 2016 through a unique partnership between Colorado State University-Pueblo, the State of Colorado, and Pueblo County. The mission of the ICR is to generate new knowledge and understanding of cannabis through innovative research, education, and dissemination of results and information. This presentation will include background information on the ICR and its activities, a discussion of trends in cannabis research in the United States, and results from some research projects supported through the ICR. The first project focuses the development of an efficient extraction method for the recovery of the cannabinoid cannabidiol (CBD) from industrial hemp (< 0.3% Δ9-tetrahydrocannabinol) using pressurized liquid extraction (PLE). This unique PLE method includes a dual extraction process in which the hemp undergoes a pre-extraction with water to promote decarboxylation of cannabidiolic acid (CBD-A) to CBD, without significant loss of neutral cannabinoids, followed by PLE using ethanol to extract the CBD. This PLE method can be employed to efficiently carry out decarboxylation of other acidic cannabinoids to their neutral counterparts. A second project that will be discussed is an interrupted time series analysis was conducted to assess the impact of Colorado’s legalization of both medical (2000) and recreational (2014) cannabis over the time period 1999 - 2018. Both were associated with a reduction of opioid overdose mortality rates. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado. The final projects that will be discussed aim at showing mechanisms which underlie effects of various cannabinoids on learning and memory in a rodent model. Our published results have shown prominent effects of Cannabidiol on the fundamental mechanisms of learning and memory, and work in progress is showing similar effects of HU-211, a synthetic glutamate receptor inhibitor. This basic medical research involves behavioral, pharmacological, electrophysiological and histological methods and has relevance for understanding appropriate medical applications for cannabinoids to treat brain disorders ranging from Alzheimer’s disease to Post Traumatic Stress Disorder.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : Objectives Sasang Constitutional Medicine is uniquely established in the field of Korean Medicine and Eight Constitution Acupuncture which is created upon Sasang constitutional medicine is widely applied in clinics. However, there exist no established theory but hypotheses with regard to the composition of acupoints of constitution acupuncture. The purpose of this study was to compare the acupuncture method between Sasang Constitutional Medicine and Eight Constitution Medicine. Methods We reviewed a total of 11 studies found on various domestic Oriental medicine journals and 7 literature ect. with the key words of Sasang Acupuncture, Eight Constitution Acupuncture and acupoint. Results Among studies and literature chosen, the application of Saam’s acupucture method was many. Eight Constitution Medicine method is applied in the various disease and clinical studies were increased after the year 2000. Conclusion Although there were vulnerable approached to its theoretical and clinical evidence, further study should be followed to establish proper method of constitutional acupuncture.

    Abstract
  • International Scientific Acupuncture and Meridian Symposium (ISAMS) 2019 Conference Abstracts2020-04-01

    Abstract : ALS , often referred to as “ Lou Gehring’s Disease,” is a progressive disorder that causes degeneration of the motor neurons in the spinal cord, brain stem, and motor cortex that control the voluntary muscle movement. The average ALS patient’s life span is less than three years from when symptoms first appear. Unfortunately ALS is progressive disease until death. The significant symptoms of ALS include muscle spasticity, muscle weakness, paralysis, fasciculation, impaired speaking, swallowing and breathing. Acupuncture treatments showed the high correlation with K-ALSFRS-R score and Sa-am acupuncture lung tonification. And Sa-am acupuncture lung tonification would be more effective on early stage of ALS disease. We found that Pharmacopuncture of Bee venom, Scolopendrid and Hominis Placenta attenuates neuroinflammatory events and extends survival in ALS models. We observed that Mecasin, a novel antineuroinflammatory Agent, inhibits neuroinflammatory responses and Mecasin exerts a neuroprotective effect by ameliorating oxidative stress via heme oxygenase-1 upregulation. According to analysis of clinical trial, the low dose or high dose mecasin group showed better results than the riluteck control group.

    Abstract
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